Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | ME1 | P48163 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20128652 | 0.81 | CRBN (0.52) | ADORA2APOLBCRBNALDH1A1MT-CO2 | |
| SCHEMBL22426224 | 0.80 | ALDH1A1 (0.57) | ADORA2APOLBALDH1A1GAAHPGD | |
| SCHEMBL22426225 | 0.80 | ALDH1A1 (0.57) | ADORA2APOLBALDH1A1GAAHPGD | |
| SCHEMBL23968261 | 0.80 | ADORA2A (0.45) | ADORA2APOLBALDH1A1MT-CO2ALOX5 | |
| SCHEMBL4120260 | 0.78 | ALDH1A1 (0.50) | POLBCRBNALDH1A1MT-CO2ALOX5 | |
| SCHEMBL17169711 | 0.77 | ALDH1A1 (0.60) | ADORA2APOLBALDH1A1MT-CO2ALOX5 | |
| SCHEMBL20128666 | 0.77 | ALDH1A1 (0.50) | ADORA2APOLBALDH1A1MT-CO2ALOX5 | |
| SCHEMBL24787870 | 0.75 | CRBN (0.53) | CRBNALDH1A1CYP3A4MEN1KMT2A | |
| SCHEMBL31274976 | 0.75 | MT-CO2 (0.54) | POLBALDH1A1MT-CO2ALOX5GAA | |
| SCHEMBL16446966 | 0.75 | KMT2A (0.57) | POLBALDH1A1MT-CO2ALOX5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210315896-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210315896-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | LRRK2, CRBN, MDM2 | ADORA2A 2797/4885POLB 3660/4885CRBN 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.