Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24916774 | 0.81 | CCR1 (0.52) | KCNH2SMN1; SMN2MEN1KMT2AGRM5 | |
| SCHEMBL20749289 | 0.81 | TSHR (0.55) | GAASMN1; SMN2TSHRMEN1LMNA | |
| SCHEMBL30201993 | 0.81 | CCR1 (0.52) | KCNH2SMN1; SMN2MEN1KMT2AGRM5 | |
| SCHEMBL19624877 | 0.81 | GAA (0.45) | GAAKCNH2SMN1; SMN2TSHRMEN1 | |
| SCHEMBL10144469 | 0.79 | KCNH2 (0.54) | KCNH2SMN1; SMN2MEN1KMT2AGRM5 | |
| SCHEMBL30173447 | 0.78 | KCNH2 (0.73) | KCNH2SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL1563917 | 0.78 | KCNH2 (0.73) | KCNH2SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL1562625 | 0.76 | TSHR (0.56) | GAASMN1; SMN2TSHRMEN1LMNA | |
| SCHEMBL19369541 | 0.74 | PDE10A (0.43) | KCNH2SMN1; SMN2GRM5NOS1NOS2 | |
| SCHEMBL21999201 | 0.74 | TAAR1 (0.52) | KCNH2SMN1; SMN2CYP2D6NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | GAA 2589/4885KCNH2 4564/4885SMN1; SMN2 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.