Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 2/20 | 0.47 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28724351 | 1.00 | ATF4 (0.66) | ATF4LMNAFAAHBCHEACHE | |
| SCHEMBL17656878 | 0.87 | ATF4 (0.72) | ATF4LMNAFAAHBCHEACHE | |
| SCHEMBL28721546 | 0.86 | ATF4 (0.58) | ATF4LMNAKMT2AACACBACACA | |
| SCHEMBL23920495 | 0.86 | ATF4 (0.58) | ATF4LMNAKMT2AACACBACACA | |
| SCHEMBL22777515 | 0.84 | ATF4 (0.76) | ATF4LMNAFAAHBCHEACHE | |
| SCHEMBL22777525 | 0.84 | ATF4 (0.65) | ATF4LMNAFAAHBCHEACHE | |
| SCHEMBL22777528 | 0.84 | ATF4 (0.65) | ATF4LMNAFAAHBCHEACHE | |
| SCHEMBL23920294 | 0.83 | ATF4 (0.60) | ATF4FAAHBCHEACHEACACB | |
| SCHEMBL20632012 | 0.82 | ATF4 (0.64) | ATF4LMNAKMT2A | |
| SCHEMBL22777409 | 0.81 | ATF4 (0.70) | ATF4LMNAFAAHBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983378-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2022-04-20 | — | — | EP | disclosed |
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885LMNA 4459/4885FAAH 2722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.