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SCHEMBL20632012

SCHEMBL20632012

CC(C)(C)OC(=O)NC1CC(NC(=O)COc2ccc(Cl)cc2)C1

nearest known ligand 0.64

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ATF4 P18848 5/20 0.64
▸ KMT2A Q03164 2/20 0.48
▸ LMNA P02545 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17658585 0.87 ATF4 (0.82) ATF4KMT2ALMNAALDH1A1
SCHEMBL17658644 0.87 ATF4 (0.82) ATF4KMT2ALMNAALDH1A1
SCHEMBL20632038 0.85 ATF4 (0.53) ATF4KMT2AALDH1A1L3MBTL1
SCHEMBL23920510 0.82 ATF4 (0.66) ATF4KMT2ALMNA
SCHEMBL28724351 0.82 ATF4 (0.66) ATF4KMT2ALMNA
SCHEMBL23294711 0.82 ATF4 (0.56) ATF4KMT2ALMNAALDH1A1
SCHEMBL21882045 0.82 ATF4 (0.76) ATF4ALDH1A1
SCHEMBL23294709 0.82 ATF4 (0.56) ATF4KMT2ALMNAALDH1A1
SCHEMBL21390220 0.82 ATF4 (0.56) ATF4KMT2ALMNAALDH1A1
SCHEMBL23294710 0.82 ATF4 (0.56) ATF4KMT2ALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019008506-A1 N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-10 — — WO disclosed