Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22144708 | 0.85 | GAA (0.36) | CRBNDDB1PTGS1TOP2ATOP2B | |
| SCHEMBL22414491 | 0.82 | ALOX5 (0.34) | CRBNDDB1PTGS1TOP2ATOP2B | |
| SCHEMBL14006967 | 0.80 | DDB1 (0.42) | CRBNDDB1PTGS1TOP2ATOP2B | |
| SCHEMBL13349250 | 0.80 | TOP2A (0.44) | CRBNPTGS1TOP2ATOP2BLMNA | |
| SCHEMBL6534633 | 0.80 | TOP2A (0.44) | CRBNPTGS1TOP2ATOP2BLMNA | |
| SCHEMBL6534567 | 0.80 | TOP2A (0.44) | CRBNPTGS1TOP2ATOP2BLMNA | |
| SCHEMBL6824267 | 0.79 | CRBN (0.38) | CRBNDDB1TOP2ATOP2BGAA | |
| SCHEMBL25906427 | 0.76 | CRBN (0.36) | CRBNDDB1TOP2ATOP2BGAA | |
| SCHEMBL13105463 | 0.75 | — | — | |
| SCHEMBL12253555 | 0.74 | BRD4 (0.44) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213543-A1 | BISULFITE-FREE, BASE-RESOLUTION IDENTIFICATION OF CYTOSINE MODIFICATIONS | LUDWIG INSTITUTE FOR CANCER RESEARCH, LTD (CH) | 2022-07-07 | — | — | US | disclosed |
| US-20210317519-A1 | BISULFITE-FREE, BASE-RESOLUTION IDENTIFICATION OF CYTOSINE MODIFICATIONS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2021-10-14 | — | — | US | disclosed |