Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534633 | 1.00 | TOP2A (0.44) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL13349250 | 1.00 | TOP2A (0.44) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL26178937 | 0.84 | TOP2A (0.42) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL9653018 | 0.82 | TOP2A (0.41) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL632187 | 0.82 | TOP2A (0.43) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL6237195 | 0.82 | TOP2A (0.43) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL6662368 | 0.82 | TOP2A (0.43) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL23920828 | 0.80 | CRBN (0.35) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL378251 | 0.78 | TOP2A (0.50) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL16597500 | 0.78 | TOP2A (0.50) | TOP2ATOP2BPTGS1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6830904-B2 | Producing single diastereomers of isoleucine in high stereochemical purity by converting (R)-2-methylbutyraldehyde to a diastereomeric mixture of D-isoleucine hydantoin and L-allo-isoleucine hydantoin (5S-((R)-1-methylpropyl)hydantoin) | BIOCATALYTICS, INC. | 2004-12-14 | — | — | US | disclosed |
| US-20040048342-A1 | Methods for producing diastereomers of isoleucine | CODEXIS, INC. | 2004-03-11 | — | — | US | disclosed |