SCHEMBL23920859

SCHEMBL23920859

CSc1nc2c(=O)n3cc(-c4ccc(F)cc4)[nH]c3nc2n1CCO

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 6/20 0.46
ADORA1 P30542 2/20 0.40
MAPK14 Q16539 8/20 0.39
LMNA P02545 1/20 0.36
MAPK13 O15264 2/20 0.34
MAPK12 P53778 2/20 0.34
MAPK11 Q15759 2/20 0.34
AXL P30530 1/20 0.32
KEAP1 Q14145 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23921233 0.90 ADORA3 (0.51) ADORA3ADORA1LMNA
SCHEMBL23921020 0.89 ADORA3 (0.47) ADORA3ADORA1LMNA
SCHEMBL23920864 0.85 ADORA3 (0.45) ADORA3ADORA1LMNA
SCHEMBL23921079 0.85 ADORA3 (0.46) ADORA3ADORA1
SCHEMBL23920978 0.82 ADORA3 (0.52) ADORA3ADORA1
SCHEMBL23920870 0.79 ADORA3 (0.52) ADORA3ADORA1
SCHEMBL23920877 0.78 ADORA3 (0.49) ADORA3ADORA1
SCHEMBL23921155 0.78 ADORA3 (0.46) ADORA3ADORA1LMNA
SCHEMBL21396510 0.78 ADORA3 (0.46) ADORA3ADORA1
SCHEMBL23920929 0.77 ADORA3 (0.46) ADORA3ADORA1LMNARXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242568-A1 POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES MIRECA MEDICINES GMBH (DE) 2023-08-03 US disclosed
US-20210317156-A1 NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES MIRECA MEDICINES GMBH (DE) 2021-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242568-A1 POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES PRKG1, PRKG2, PRKAG3 ADORA3 425/4885ADORA1 857/4885MAPK14 626/4885
US-20210317156-A1 NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES PRKG1, PRKG2, PDE7A ADORA3 449/4885ADORA1 828/4885MAPK14 657/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.