SCHEMBL23920862

SCHEMBL23920862

Nc1nc2c(nc(SCc3cccc(B(O)O)c3)n2CCO)c(=O)[nH]1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PNP P00491 7/20 0.43
KDM1A O60341 2/20 0.39
IDO1 P14902 1/20 0.38
TK1 P04183 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
KMT2A Q03164 1/20 0.36
THRB P10828 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23921136 0.88 PNP (0.42) PNPKDM1AIDO1TK1MAPT
SCHEMBL23921073 0.82 MEN1 (0.42) POLBMAPTKMT2ARXFP1
SCHEMBL23920921 0.81 PNP (0.44) PNPKDM1AIDO1TK1MAPT
SCHEMBL23921217 0.81 PNP (0.35) PNPPOLBMAPTKMT2ARXFP1
SCHEMBL23920830 0.81 PNP (0.43) PNPTK1POLBKMT2A
SCHEMBL23921066 0.80 XDH (0.46) PNPKMT2A
SCHEMBL23921225 0.79 PNP (0.55) PNP
SCHEMBL23921116 0.78 CYP3A4 (0.46) PNPTK1MAPTKMT2A
SCHEMBL25932075 0.78 KDM4E (0.45) PNPTK1MAPT
SCHEMBL23920942 0.77 PNP (0.50) PNPTK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242568-A1 POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES MIRECA MEDICINES GMBH (DE) 2023-08-03 US disclosed
US-20210317156-A1 NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES MIRECA MEDICINES GMBH (DE) 2021-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242568-A1 POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES PRKG1, PRKG2, PRKAG3 PNP 111/4885KDM1A 1545/4885IDO1 2576/4885
US-20210317156-A1 NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES PRKG1, PRKG2, PDE7A PNP 106/4885KDM1A 1720/4885IDO1 2714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.