SCHEMBL23922737

SCHEMBL23922737

CCCCOC(=O)N1C(=O)C(O[Si](C)(C)C(C)(C)C)CC1C(=O)OC

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
POLB P06746 1/20 0.34
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
CYP3A4 P08684 2/20 0.30
MAPT P10636 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5455578 0.90 MAPT (0.34) POLBALDH1A1CYP3A4MAPT
SCHEMBL12192438 0.82 PTPN1 (0.34) SMN1; SMN2
SCHEMBL2353368 0.82 PTPN1 (0.34) SMN1; SMN2
SCHEMBL18204848 0.82 PTPN1 (0.34) SMN1; SMN2
SCHEMBL15122945 0.82 PTPN1 (0.34) SMN1; SMN2
SCHEMBL2494727 0.82 PTPN1 (0.34) SMN1; SMN2
SCHEMBL31234416 0.82 PTPN1 (0.34) SMN1; SMN2
SCHEMBL2494729 0.82 PTPN1 (0.34) SMN1; SMN2
SCHEMBL15130143 0.80 MMP2 (0.31) KMT2A
SCHEMBL18612437 0.76 GLA (0.34) ALDH1A1TSHRKMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3447052-B1 METHODS OF PREPARING NEW IDH1 INHIBITORS LES LABORATOIRES SERVIER SAS (FR) 2021-10-20 EP disclosed