Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.59 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.51 |
| ▸ | CYP21A2 | P08686 | 4/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21292774 | 0.85 | ALDH1A1 (0.62) | ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E | |
| SCHEMBL3077544 | 0.83 | TRIM24 (0.83) | ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E | |
| SCHEMBL2561698 | 0.83 | TRIM24 (0.83) | ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E | |
| SCHEMBL82680 | 0.80 | MEN1 (0.69) | ALDH1A1SMN1; SMN2KDM4EPOLBMEN1 | |
| SCHEMBL974007 | 0.79 | POLB (0.54) | ALDH1A1SMN1; SMN2KDM4EPOLBMEN1 | |
| SCHEMBL941084 | 0.79 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2POLBCYP17A1CYP21A2 | |
| SCHEMBL20004452 | 0.79 | POLB (0.54) | ALDH1A1SMN1; SMN2KDM4EPOLBMEN1 | |
| SCHEMBL6152910 | 0.79 | MAPT (0.58) | ALDH1A1SMN1; SMN2KDM4EPOLBMEN1 | |
| SCHEMBL1926789 | 0.79 | MAPT (0.58) | ALDH1A1SMN1; SMN2KDM4EPOLBMEN1 | |
| SCHEMBL2453453 | 0.79 | MAPT (0.59) | ALDH1A1SMN1; SMN2KDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481824-B1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2021-10-20 | — | — | EP | disclosed |
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |