Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | BACE1 | P56817 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25187320 | 0.81 | NR1H2 (0.46) | ALDH1A1KDM4ELMNA | |
| SCHEMBL4030428 | 0.81 | SCN9A (0.41) | ALDH1A1KDM4EKMT2ALMNATSHR | |
| SCHEMBL23925096 | 0.80 | ALDH1A1 (0.38) | ALDH1A1KDM4EKMT2ALMNATSHR | |
| SCHEMBL1583698 | 0.80 | HTR2C (0.41) | ALDH1A1KDM4EKMT2ALMNATSHR | |
| SCHEMBL4027232 | 0.73 | KMT2A (0.47) | ALDH1A1KDM4EKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1394514 | 0.71 | POLB (0.50) | ALDH1A1KDM4EKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4026763 | 0.71 | TACR1 (0.42) | KMT2A | |
| SCHEMBL4025816 | 0.71 | TACR1 (0.42) | KMT2A | |
| SCHEMBL2656685 | 0.70 | MTNR1A (0.42) | KMT2AMEN1PKM | |
| SCHEMBL27567696 | 0.70 | HDAC1 (0.43) | ALDH1A1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4136084-A1 | BCL-2 INHIBITOR | BeiGene, Ltd. (KY) | 2023-02-22 | — | — | EP | disclosed |
| WO-2021208963-A1 | BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-10-21 | — | — | WO | disclosed |