Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30198468 | 1.00 | MEN1 (0.52) | MEN1KMT2AHSP90AA1ALDH1A1GAA | |
| SCHEMBL16110049 | 0.81 | PDGFRB (0.43) | MEN1KMT2AMAPTSMN1; SMN2HCAR3 | |
| SCHEMBL5789975 | 0.80 | MEN1 (0.46) | MEN1KMT2AHSP90AA1ALDH1A1GAA | |
| SCHEMBL1040683 | 0.80 | MEN1 (0.43) | MEN1KMT2AHSP90AA1ALDH1A1GAA | |
| SCHEMBL30746848 | 0.80 | MEN1 (0.43) | MEN1KMT2AHSP90AA1ALDH1A1GAA | |
| SCHEMBL2875869 | 0.79 | SLC6A3 (0.38) | MEN1KMT2AHSP90AA1ALDH1A1GAA | |
| SCHEMBL30258140 | 0.78 | KMT2A (0.42) | MEN1KMT2AHSP90AA1ALDH1A1GAA | |
| SCHEMBL25302825 | 0.78 | KMT2A (0.42) | MEN1KMT2AHSP90AA1ALDH1A1GAA | |
| SCHEMBL14249660 | 0.78 | PDGFRB (0.43) | MEN1KMT2AHSP90AA1ALDH1A1GAA | |
| SCHEMBL5740305 | 0.77 | MEN1 (0.41) | MEN1KMT2AHSP90AA1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227411-A1 | Benzimidazole Derivatives | HOFFMANN-LA ROCHE INC. (US) | 2023-07-20 | — | — | US | disclosed |
| EP-4136078-A1 | BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-02-22 | — | — | EP | disclosed |
| CN-115443268-A | Benzimidazole derivatives | 豪夫迈·罗氏有限公司 | 2022-12-06 | — | — | CN | disclosed |
| WO-2021209485-A1 | BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227411-A1 | Benzimidazole Derivatives | CCNI, CCNB3, CYP3A43 | MEN1 1239/4885KMT2A 1768/4885HSP90AA1 2519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.