Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK2 | Q9H0K1 | 15/20 | 0.59 |
| ▸ | SIK3 | Q9Y2K2 | 15/20 | 0.59 |
| ▸ | SIK1 | P57059 | 13/20 | 0.59 |
| ▸ | ABL1 | P00519 | 15/20 | 0.58 |
| ▸ | SRC | P12931 | 5/20 | 0.54 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.52 |
| ▸ | BCR | P11274 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | YES1 | P07947 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | HCK | P08631 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927240 | 0.85 | SIK2 (0.62) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL23927272 | 0.84 | ABL1 (0.51) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL23927239 | 0.81 | SIK2 (0.76) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL30152001 | 0.77 | SIK2 (0.81) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL23927241 | 0.77 | SIK2 (0.81) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL4257532 | 0.75 | SIK2 (0.67) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL31307340 | 0.75 | SIK2 (0.89) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL23987816 | 0.75 | SIK2 (0.89) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL23987799 | 0.75 | SIK2 (0.62) | SIK2SIK3SIK1ABL1SRC | |
| SCHEMBL23927249 | 0.74 | SIK2 (0.85) | SIK2SIK3SIK1ABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3901151-A1 | HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF | iOmx Therapeutics AG (DE) | 2021-10-27 | — | — | EP | disclosed |