Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.52 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | DRD4 | P21917 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 5/20 | 0.46 |
| ▸ | IDH1 | O75874 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12778108 | 0.77 | CYP19A1 (0.56) | CYP19A1IMPDH2IMPDH1DRD2DRD4 | |
| SCHEMBL317688 | 0.77 | CYP19A1 (0.56) | CYP19A1IMPDH2IMPDH1DRD2DRD4 | |
| SCHEMBL28863016 | 0.77 | CYP19A1 (0.56) | CYP19A1IMPDH2IMPDH1DRD2DRD4 | |
| SCHEMBL28984930 | 0.77 | CYP19A1 (0.56) | CYP19A1IMPDH2IMPDH1DRD2DRD4 | |
| SCHEMBL15058859 | 0.74 | CYP19A1 (0.81) | CYP19A1IMPDH2IMPDH1ITK | |
| SCHEMBL1054605 | 0.73 | CA12 (0.56) | CYP19A1IMPDH2IMPDH1CA1CA2 | |
| SCHEMBL6989797 | 0.73 | DRD2 (0.58) | CYP19A1IMPDH2IMPDH1DRD2DRD4 | |
| SCHEMBL10022421 | 0.73 | CYP19A1 (0.51) | CYP19A1IMPDH2IMPDH1DRD2DRD4 | |
| SCHEMBL1420556 | 0.73 | CYP19A1 (0.51) | CYP19A1IMPDH2IMPDH1DRD2DRD4 | |
| SCHEMBL12804152 | 0.73 | CYP19A1 (0.51) | CYP19A1IMPDH2IMPDH1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112823157-B | Spirochroman derivatives | 吉瑞工厂 | 2024-08-09 | — | — | CN | disclosed |
| EP-3820869-B1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2023-08-30 | — | — | EP | disclosed |
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2021-10-28 | — | — | US | disclosed |
| CN-112823157-A | Spirochroman derivatives | 吉瑞工厂 | 2021-05-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | CHRNA7, CHRM3, ADRB3 | CYP19A1 1483/4885IMPDH2 2922/4885IMPDH1 2498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.