Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.58 |
| ▸ | DRD4 | P21917 | 6/20 | 0.58 |
| ▸ | DRD3 | P35462 | 6/20 | 0.58 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | IDH1 | O75874 | 4/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794338 | 0.85 | CYP19A1 (0.57) | DRD2DRD4DRD3CYP19A1IMPDH2 | |
| SCHEMBL6990646 | 0.85 | DRD2 (0.49) | DRD2DRD4DRD3LOXL2CYP19A1 | |
| SCHEMBL6826452 | 0.83 | LOXL2 (0.64) | LOXL2CYP19A1SIRT1F2PCSK9 | |
| SCHEMBL3260101 | 0.81 | DRD2 (0.49) | DRD2DRD4DRD3CYP19A1F2 | |
| SCHEMBL6991388 | 0.78 | LOXL2 (0.49) | DRD2DRD4DRD3LOXL2F2 | |
| SCHEMBL6984195 | 0.78 | LOXL2 (0.49) | DRD2DRD4DRD3LOXL2SIRT1 | |
| SCHEMBL9530334 | 0.78 | MEN1 (0.49) | LOXL2SIRT1F2PCSK9 | |
| SCHEMBL6989926 | 0.78 | LOXL2 (0.49) | LOXL2CYP19A1SIRT1F2PCSK9 | |
| SCHEMBL6994727 | 0.78 | LOXL2 (0.57) | LOXL2SIRT1F2PCSK9 | |
| SCHEMBL9534394 | 0.78 | LOXL2 (0.40) | DRD2DRD4DRD3LOXL2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |