Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918958 | 0.88 | HSD11B1 (0.59) | CHRNA7HSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL19030659 | 0.82 | EPHX2 (0.39) | CHRNA7HSD11B1 | |
| SCHEMBL23928845 | 0.82 | CHRNA7 (0.51) | CHRNA7HSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL17708825 | 0.81 | CHRNA7 (0.50) | CHRNA7HSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL23928896 | 0.81 | SIGMAR1 (0.53) | CHRNA7HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL29920633 | 0.80 | HSD11B1 (0.48) | CHRNA7HSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL21617956 | 0.79 | CHRNA7 (0.50) | CHRNA7HSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL2588090 | 0.78 | HSD11B1 (0.72) | HSD11B1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL620216 | 0.77 | KDM4E (0.52) | CHRNA7HSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL29920628 | 0.77 | KDM4E (0.52) | CHRNA7HSD11B1HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820869-B1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2023-08-30 | — | — | EP | disclosed |
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | CHRNA7, CHRM3, ADRB3 | CHRNA7 1/4885HSD11B1 157/4885HDAC8 222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.