Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.44 |
| ▸ | JAK3 | P52333 | 16/20 | 0.44 |
| ▸ | JAK1 | P23458 | 9/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29986979 | 1.00 | JAK2 (0.44) | JAK2JAK3JAK1TYK2PRKDC | |
| SCHEMBL1781369 | 0.88 | HCAR1 (0.48) | JAK2JAK3JAK1TYK2HCAR1 | |
| SCHEMBL29501865 | 0.86 | HCAR1 (0.50) | JAK2JAK3JAK1HCAR1CCNE2 | |
| SCHEMBL1693604 | 0.86 | HCAR1 (0.50) | JAK2JAK3JAK1HCAR1CCNE2 | |
| SCHEMBL20299440 | 0.85 | JAK2 (0.47) | JAK2JAK3JAK1TYK2PRKDC | |
| SCHEMBL29770995 | 0.85 | JAK2 (0.47) | JAK2JAK3JAK1TYK2PRKDC | |
| SCHEMBL1693606 | 0.84 | JAK2 (0.59) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL20359146 | 0.84 | JAK2 (0.54) | JAK2JAK3JAK1TYK2PRKDC | |
| SCHEMBL23974060 | 0.84 | JAK2 (0.44) | JAK2JAK3JAK1TYK2PRKDC | |
| SCHEMBL20329966 | 0.84 | JAK2 (0.54) | JAK2JAK3JAK1TYK2PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113549092-B | Tricyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2022-10-18 | — | — | CN | disclosed |
| WO-2021213460-A1 | TRICYCLIC KINASE INHIBITOR | 山东轩竹医药科技有限公司 (CN) | 2021-10-28 | — | — | WO | disclosed |
| WO-2021213460-A1 | TRICYCLIC KINASE INHIBITOR | 山东轩竹医药科技有限公司 (CN) | 2021-10-28 | — | — | WO | disclosed |
| CN-113549092-A | Tricyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2021-10-26 | — | — | CN | disclosed |