Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 10/20 | 0.48 |
| ▸ | JAK3 | P52333 | 10/20 | 0.48 |
| ▸ | JAK1 | P23458 | 7/20 | 0.48 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501865 | 0.99 | HCAR1 (0.50) | HCAR1JAK2JAK3JAK1MAP3K11 | |
| SCHEMBL1693604 | 0.99 | HCAR1 (0.50) | HCAR1JAK2JAK3JAK1MAP3K11 | |
| SCHEMBL21593673 | 0.89 | JAK2 (0.43) | HCAR1JAK2JAK3JAK1MAP3K11 | |
| SCHEMBL29770995 | 0.89 | JAK2 (0.47) | HCAR1JAK2JAK3JAK1CCNE2 | |
| SCHEMBL20299440 | 0.89 | JAK2 (0.47) | HCAR1JAK2JAK3JAK1CCNE2 | |
| SCHEMBL23974060 | 0.88 | JAK2 (0.44) | HCAR1JAK2JAK3JAK1CCNE2 | |
| SCHEMBL1693606 | 0.88 | JAK2 (0.59) | JAK2JAK3JAK1MTORCHRM2 | |
| SCHEMBL23929312 | 0.88 | JAK2 (0.44) | HCAR1JAK2JAK3JAK1CCNE2 | |
| SCHEMBL20329966 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1MAP3K11MTOR | |
| SCHEMBL23452644 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1MAP3K11MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-05-19 | — | — | US | disclosed |
| EP-2212326-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009024824-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BUB1, BUB1B, TTBK1 | HCAR1 4228/4885JAK2 761/4885JAK3 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.