Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987032 | 1.00 | CYP1A2 (0.39) | CYP1A2ALDH1A1HSD17B10CYP3A4CLK4 | |
| SCHEMBL23929329 | 0.86 | CYP1A2 (0.41) | CYP1A2ALDH1A1HSD17B10CYP3A4CLK4 | |
| SCHEMBL29987849 | 0.86 | CYP1A2 (0.41) | CYP1A2ALDH1A1HSD17B10CYP3A4CLK4 | |
| SCHEMBL23929314 | 0.83 | CYP1A2 (0.33) | CYP1A2ALDH1A1HSD17B10CYP3A4CLK4 | |
| SCHEMBL29987360 | 0.83 | CYP1A2 (0.33) | CYP1A2ALDH1A1HSD17B10CYP3A4CLK4 | |
| SCHEMBL23929316 | 0.83 | MAPK8 (0.42) | CYP1A2ALDH1A1HSD17B10CYP3A4CLK4 | |
| SCHEMBL29987529 | 0.83 | MAPK8 (0.42) | CYP1A2ALDH1A1HSD17B10CYP3A4CLK4 | |
| SCHEMBL29986491 | 0.81 | CYP1A2 (0.34) | CYP1A2ALDH1A1HSD17B10CYP3A4MEN1 | |
| SCHEMBL23929301 | 0.81 | CYP1A2 (0.34) | CYP1A2ALDH1A1HSD17B10CYP3A4MEN1 | |
| SCHEMBL16084167 | 0.79 | CYP11B2 (0.43) | CYP1A2CYP3A4JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493471-B | Heteroaromatic kinase inhibitors | 山东轩竹医药科技有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-116023393-A | Crystal forms of tricyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-116023394-A | Crystal forms of tricyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-116023395-A | Crystal forms of tricyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-113549092-B | Tricyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2022-10-18 | — | — | CN | disclosed |
| WO-2021213460-A1 | TRICYCLIC KINASE INHIBITOR | 山东轩竹医药科技有限公司 (CN) | 2021-10-28 | — | — | WO | disclosed |
| WO-2021213460-A1 | TRICYCLIC KINASE INHIBITOR | 山东轩竹医药科技有限公司 (CN) | 2021-10-28 | — | — | WO | disclosed |
| CN-113549092-A | Tricyclic kinase inhibitors | 山东轩竹医药科技有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-113493471-A | Heteroaromatic kinase inhibitors | 山东轩竹医药科技有限公司 | 2021-10-12 | — | — | CN | disclosed |