Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 14/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395258 | 0.82 | PTGDR2 (0.43) | PTGDR2POLB | |
| SCHEMBL27849060 | 0.82 | PTGDR2 (0.47) | PTGDR2MCL1TTRCHRM1 | |
| SCHEMBL2398768 | 0.82 | PTGDR2 (0.55) | PTGDR2MCL1POLBTTRCHRM1 | |
| SCHEMBL1331643 | 0.80 | PTGDR2 (0.54) | PTGDR2POLB | |
| SCHEMBL1333653 | 0.78 | PTGDR2 (0.58) | PTGDR2MCL1TTR | |
| SCHEMBL27849129 | 0.78 | PTGDR2 (0.51) | PTGDR2MCL1TTRCHRM1FFAR1 | |
| SCHEMBL28330663 | 0.78 | PTGDR2 (0.58) | PTGDR2MCL1TTR | |
| SCHEMBL27849058 | 0.77 | ALDH1A1 (0.47) | PTGDR2 | |
| SCHEMBL1333658 | 0.76 | PTGDR2 (0.52) | PTGDR2MCL1POLBTTR | |
| SCHEMBL1332548 | 0.76 | PTGDR2 (0.71) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022248-B2 | 3-[2-(3-Cyanophenoxy)-4-(trifluoromethyl)phenyl]propanoic acid;prostaglandin D2 inhibitor, orphan receptor CRTH2 antagonist; antiinflammatory, analgesic, antipyretic; respiratory system disorders: asthma and rhinitis; coupling amino/thio-phenyl derivatives with ester followed by hydrolysis to acid | ASTRAZENECA AB (SE) | 2011-09-20 | — | — | US | disclosed |