Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29257491 | 0.82 | NPSR1 (0.36) | MAPTHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL28699974 | 0.78 | AKT1 (0.46) | HTTKMT2AMEN1GAALMNA | |
| SCHEMBL27865773 | 0.76 | MLYCD (0.35) | MAPTHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL5170932 | 0.72 | SMN1; SMN2 (0.46) | MAPTHTTALDH1A1GLATSHR | |
| SCHEMBL28918184 | 0.70 | ALDH1A1 (0.31) | MAPTALDH1A1TSHRTDP1L3MBTL1 | |
| SCHEMBL28979187 | 0.69 | ALDH1A1 (0.32) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL6975370 | 0.68 | ALDH1A1 (0.42) | MAPTHTTALDH1A1GLATSHR | |
| SCHEMBL8144722 | 0.68 | SMN1; SMN2 (0.39) | HTTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL6975366 | 0.68 | ALDH1A1 (0.42) | MAPTHTTALDH1A1GLATSHR | |
| SCHEMBL17681708 | 0.68 | ALDH1A1 (0.41) | MAPTALDH1A1TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139286-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | Bayer Aktiengesellschaft (DE) | 2023-03-01 | — | — | EP | claimed |
| WO-2021214019-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2021-10-28 | — | — | WO | claimed |