Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710553 | 0.83 | NPSR1 (0.36) | NPSR1KDM4CRNASEH1LMNAKDM4E | |
| SCHEMBL26089940 | 0.83 | NPSR1 (0.36) | NPSR1KDM4CRNASEH1LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL7883592 | 0.81 | NPSR1 (0.44) | NPSR1KDM4CRNASEH1LMNAERCC1 | |
| SCHEMBL784 | 0.81 | NPSR1 (0.44) | NPSR1KDM4CRNASEH1LMNAMEN1 | |
| SCHEMBL7303318 | 0.79 | NPSR1 (0.41) | NPSR1KDM4CRNASEH1LMNAALDH1A1 | |
| SCHEMBL30663426 | 0.79 | NPSR1 (0.41) | NPSR1KDM4CRNASEH1LMNAKDM4E | |
| SCHEMBL2517694 | 0.77 | NPSR1 (0.50) | NPSR1KDM4CRNASEH1LMNAERCC1 | |
| SCHEMBL9277960 | 0.75 | RNASEH1 (0.70) | NPSR1RNASEH1LMNAERCC1FEN1 | |
| SCHEMBL14736371 | 0.74 | NPSR1 (0.52) | NPSR1KDM4CRNASEH1LMNAERCC1 | |
| SCHEMBL28218383 | 0.73 | RNASEH1 (0.53) | NPSR1RNASEH1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323364-A1 | IMIDAZO[4,5-D]PYRIDAZINONYL DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219015-A1 | IMIDAZO[4,5-d]PYRIDAZINONYL DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-10-20 | — | — | WO | disclosed |
| WO-2021215545-A1 | ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-10-28 | — | — | WO | disclosed |