Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 2/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21721397 | 0.81 | ALDH1A1 (0.39) | POLBNPC1RAB9ANPSR1CA12 | |
| SCHEMBL23930969 | 0.81 | GABRA1 (0.36) | APOBEC3AAPOBEC3GALDH1A1TP53CYP1A2 | |
| SCHEMBL22697032 | 0.81 | MAPK1 (0.43) | APOBEC3AAPOBEC3GNPC1RAB9ACA12 | |
| SCHEMBL71364 | 0.79 | APOBEC3A (0.46) | APOBEC3AAPOBEC3GFGFR1NPSR1ALDH1A1 | |
| SCHEMBL21880074 | 0.79 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GPOLBLMNAGRM5 | |
| SCHEMBL23992032 | 0.78 | APOBEC3A (0.38) | APOBEC3AAPOBEC3GNPC1RAB9AFGFR1 | |
| SCHEMBL23930914 | 0.78 | APOBEC3A (0.38) | APOBEC3AAPOBEC3GNPC1RAB9AFGFR1 | |
| SCHEMBL31333068 | 0.78 | APOBEC3A (0.38) | APOBEC3AAPOBEC3GRAB9AFGFR1NPSR1 | |
| SCHEMBL31332992 | 0.77 | NPC1 (0.43) | APOBEC3AAPOBEC3GNPC1ALDH1A1LMNA | |
| SCHEMBL31332887 | 0.74 | CYP11B1 (0.38) | APOBEC3AAPOBEC3GFGFR1NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021215545-A1 | ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-10-28 | — | — | WO | disclosed |