Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874724 | 0.89 | PTGDR2 (0.48) | PTGDR2EPAS1HTR2ASLC6A4KCNH2 | |
| SCHEMBL5574572 | 0.87 | PTGDR2 (0.47) | PTGDR2EPAS1HTR2ASLC6A4KCNH2 | |
| SCHEMBL5574574 | 0.84 | PTGDR2 (0.45) | PTGDR2EPAS1HTR2ASLC6A4KCNH2 | |
| SCHEMBL2398431 | 0.80 | MRGPRX4 (0.46) | PTGDR2EPAS1NPSR1HTR2ASLC6A4 | |
| SCHEMBL2393446 | 0.79 | PPARG (0.47) | PTGDR2EPAS1VEGFAMRGPRX4 | |
| SCHEMBL21223103 | 0.77 | ALDH1A1 (0.43) | SMN1; SMN2CYP2C9CYP1A2CYP2C19HTR2A | |
| SCHEMBL2395800 | 0.76 | EPAS1 (0.46) | PTGDR2EPAS1NPSR1HTR2ASLC6A4 | |
| SCHEMBL27309402 | 0.75 | ELANE (0.44) | PTGDR2KDM4EHTTSMN1; SMN2CYP2C9 | |
| SCHEMBL5570087 | 0.73 | EPAS1 (0.42) | PTGDR2EPAS1HTR2ASLC6A4KCNH2 | |
| SCHEMBL2393359 | 0.73 | PTGDR2 (0.46) | PTGDR2KDM4EHTTSMN1; SMN2EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022248-B2 | 3-[2-(3-Cyanophenoxy)-4-(trifluoromethyl)phenyl]propanoic acid;prostaglandin D2 inhibitor, orphan receptor CRTH2 antagonist; antiinflammatory, analgesic, antipyretic; respiratory system disorders: asthma and rhinitis; coupling amino/thio-phenyl derivatives with ester followed by hydrolysis to acid | ASTRAZENECA AB (SE) | 2011-09-20 | — | — | US | disclosed |