Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 7/20 | 0.42 |
| ▸ | VEGFA | P15692 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395800 | 0.94 | EPAS1 (0.46) | EPAS1VEGFAMRGPRX4HTR2ASLC6A4 | |
| SCHEMBL2398431 | 0.76 | MRGPRX4 (0.46) | EPAS1VEGFAMRGPRX4HTR2ASLC6A4 | |
| SCHEMBL2393357 | 0.73 | PTGDR2 (0.43) | EPAS1VEGFAMRGPRX4HTR2ASLC6A4 | |
| SCHEMBL4874724 | 0.73 | PTGDR2 (0.48) | EPAS1VEGFAMRGPRX4HTR2ASLC6A4 | |
| SCHEMBL2393446 | 0.73 | PPARG (0.47) | EPAS1VEGFAMRGPRX4PTGDR2 | |
| SCHEMBL5574572 | 0.71 | PTGDR2 (0.47) | EPAS1VEGFAMRGPRX4HTR2ASLC6A4 | |
| SCHEMBL29777469 | 0.71 | MRGPRX4 (0.48) | EPAS1VEGFAMRGPRX4PTGDR2AR | |
| SCHEMBL2394657 | 0.69 | EPAS1 (0.46) | EPAS1VEGFAMRGPRX4PTGDR2AR | |
| SCHEMBL5574574 | 0.69 | PTGDR2 (0.45) | EPAS1VEGFAMRGPRX4HTR2ASLC6A4 | |
| SCHEMBL3712674 | 0.69 | TRPV4 (0.39) | HTR2AKCNH2SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765768-A1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006005909-A1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2006-01-19 | — | — | WO | disclosed |