Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23523234 | 1.00 | CHRNB2 (0.46) | CHRNB2CHRNA4ATXN2LMNAHTT | |
| SCHEMBL20936874 | 0.84 | NR1H2 (0.52) | CHRNB2CHRNA4LMNAKMT2A | |
| SCHEMBL23545096 | 0.84 | NR1H2 (0.52) | CHRNB2CHRNA4LMNAKMT2A | |
| SCHEMBL24608255 | 0.84 | NR1H2 (0.52) | CHRNB2CHRNA4LMNAKMT2A | |
| SCHEMBL4979209 | 0.82 | CHRNB2 (0.42) | CHRNB2CHRNA4LMNAHTTMEN1 | |
| SCHEMBL23523231 | 0.81 | LMNA (0.35) | CHRNB2CHRNA4LMNAHTTFAAH | |
| SCHEMBL23523228 | 0.81 | LMNA (0.35) | CHRNB2CHRNA4LMNAHTTFAAH | |
| SCHEMBL23523229 | 0.81 | LMNA (0.35) | CHRNB2CHRNA4LMNAHTTFAAH | |
| SCHEMBL22609209 | 0.79 | CHRNB2 (0.40) | CHRNB2CHRNA4LMNAHTTMEN1 | |
| SCHEMBL20919479 | 0.77 | CHRNB2 (0.39) | CHRNB2CHRNA4LMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139303-A1 | CONDENSED SUBSTITUTED HYDROPYRROLES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021216951-A1 | CONDENSED SUBSTITUTED HYDROPYRROLES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2021-10-28 | — | — | WO | disclosed |