Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23935156 | 0.85 | GABRA1 (0.35) | PIM1FLT3 | |
| SCHEMBL23935193 | 0.85 | GABRA1 (0.35) | LRRK2 | |
| SCHEMBL23935066 | 0.83 | GABRA1 (0.39) | GRIN1GRIN2BPIK3CBPIK3CDCDK9 | |
| SCHEMBL23934985 | 0.77 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL18606456 | 0.77 | LRRK2 (0.52) | LRRK2GRIN1GRIN2BPIK3CAGSK3B | |
| SCHEMBL18659043 | 0.75 | GRIN1 (0.40) | LRRK2GRIN1GRIN2BPIK3CAGSK3B | |
| SCHEMBL18606528 | 0.75 | LRRK2 (0.36) | LRRK2GRIN1GRIN2BIRAK4CDK8 | |
| SCHEMBL18658646 | 0.74 | F2 (0.43) | LRRK2GRIN1GRIN2BCDK8 | |
| SCHEMBL18659040 | 0.73 | LRRK2 (0.37) | LRRK2GRIN1GRIN2BPIK3CAGSK3B | |
| SCHEMBL18659045 | 0.73 | LRRK2 (0.38) | LRRK2GRIN1GRIN2BPIK3CAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |