Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 3/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18659043 | 0.86 | GRIN1 (0.40) | GRIN1GRIN2BLRRK2GSK3BKCNH2 | |
| SCHEMBL18606427 | 0.84 | CCNC (0.38) | GRIN1GRIN2BLMNAMAPTF10 | |
| SCHEMBL18606456 | 0.82 | LRRK2 (0.52) | GRIN1GRIN2BLRRK2ALDH1A1GSK3B | |
| SCHEMBL18658646 | 0.81 | F2 (0.43) | GRIN1GRIN2BLRRK2LMNAMAPT | |
| SCHEMBL26808288 | 0.80 | GRIN1 (0.38) | GRIN1GRIN2BLRRK2PDE5AGAK | |
| SCHEMBL18658642 | 0.80 | CHUK (0.38) | GRIN1GRIN2BLRRK2 | |
| SCHEMBL18659045 | 0.78 | LRRK2 (0.38) | GRIN1GRIN2BLRRK2GSK3B | |
| SCHEMBL18606424 | 0.78 | LRRK2 (0.53) | GRIN1GRIN2BLRRK2 | |
| SCHEMBL30154553 | 0.78 | LRRK2 (0.53) | GRIN1GRIN2BLRRK2 | |
| SCHEMBL18659044 | 0.78 | LRRK2 (0.37) | GRIN1GRIN2BLRRK2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |