Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23935054 | 0.87 | KLK1 (0.37) | KLK1KLK5TDP1GABRA1GABRG2 | |
| SCHEMBL18658675 | 0.81 | KLK1 (0.34) | KLK1KLK5TDP1GABRA1GABRG2 | |
| SCHEMBL18659011 | 0.80 | KLK1 (0.33) | KLK1KLK5TDP1GABRA1GABRG2 | |
| SCHEMBL18658913 | 0.78 | KLK1 (0.35) | KLK1KLK5TDP1GABRA1GABRG2 | |
| SCHEMBL18658914 | 0.77 | TUBB4A (0.34) | KLK1KLK5TDP1GABRA1GABRG2 | |
| SCHEMBL18658819 | 0.76 | GABRA1 (0.41) | TDP1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL23935007 | 0.74 | HTT (0.36) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18658825 | 0.74 | KLK1 (0.34) | KLK1KLK5TDP1GABRA1GABRG2 | |
| SCHEMBL25020880 | 0.73 | HTT (0.42) | TDP1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL30154907 | 0.73 | HTT (0.42) | TDP1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |