Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 9/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 15/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2541110 | 0.89 | PGR (0.40) | PGRNR3C1ESR1ARESR2 | |
| SCHEMBL2395852 | 0.87 | PGR (0.44) | PGRNR3C1ESR1ARESR2 | |
| SCHEMBL17667953 | 0.82 | NR3C1 (0.47) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL2544665 | 0.82 | MAPT (0.40) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4428816 | 0.81 | MAPT (0.44) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL2393960 | 0.80 | PGR (0.41) | PGRNR3C1ESR1ARESR2 | |
| SCHEMBL2397718 | 0.80 | PGR (0.42) | PGRNR3C1ESR1ARESR2 | |
| SCHEMBL2395353 | 0.79 | PGR (0.40) | KDM4EALDH1A1HPGDHSD17B10PGR | |
| SCHEMBL2393855 | 0.79 | PGR (0.43) | PGRNR3C1ESR1ARESR2 | |
| SCHEMBL17667944 | 0.79 | MAPT (0.39) | KDM4EALDH1A1MAPTHSD17B10PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017775-B2 | 1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20090326009-A1 | Novel 1-2-Dihydroquinoline Derivative Having Glucocorticoid Receptor Binding Activity | Santen Pharmaceutical Co., (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326009-A1 | Novel 1-2-Dihydroquinoline Derivative Having Glucocorticoid Receptor Binding Activity | NR3C1, NR3C2, NR5A1 | KDM4E 3839/4885ALDH1A1 3569/4885MAPT 4652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.