Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 10/20 | 0.58 |
| ▸ | EPAS1 | Q99814 | 18/20 | 0.53 |
| ▸ | ARNT | P27540 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18078060 | 0.88 | VEGFA (0.69) | VEGFAEPAS1ARNTCYP2C9CYP2C19 | |
| SCHEMBL18078041 | 0.84 | EPAS1 (0.71) | VEGFAEPAS1ARNTCYP2C9CYP2C19 | |
| SCHEMBL23935780 | 0.81 | EPAS1 (0.52) | VEGFAEPAS1 | |
| SCHEMBL23935887 | 0.80 | EPAS1 (0.52) | VEGFAEPAS1 | |
| SCHEMBL23935871 | 0.80 | EPAS1 (0.52) | VEGFAEPAS1 | |
| SCHEMBL28425966 | 0.80 | VEGFA (0.53) | VEGFAEPAS1ARNTCYP2C9CYP2C19 | |
| SCHEMBL30136472 | 0.80 | VEGFA (0.53) | VEGFAEPAS1ARNTCYP2C9CYP2C19 | |
| SCHEMBL28425970 | 0.80 | VEGFA (0.53) | VEGFAEPAS1ARNTCYP2C9CYP2C19 | |
| SCHEMBL30136471 | 0.80 | VEGFA (0.53) | VEGFAEPAS1ARNTCYP2C9CYP2C19 | |
| SCHEMBL28895560 | 0.80 | VEGFA (0.53) | VEGFAEPAS1ARNTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268362-B1 | SUBSTITUTED PYRIDINES AND USES THEREOF | PELOTON THERAPEUTICS INC (US) | 2021-10-20 | — | — | EP | disclosed |