Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PRKCI | P41743 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23937731 | 0.86 | PIK3CB (0.33) | PIK3CBPRKCI | |
| SCHEMBL29563716 | 0.71 | APP (0.35) | CYP19A1PIK3CBKDM4EALDH1A1PRKCI | |
| SCHEMBL20674183 | 0.71 | PIK3CB (0.34) | PIK3CBKDM4EPRKCI | |
| SCHEMBL24969101 | 0.64 | CHRNA7 (0.40) | CYP19A1PIK3CBKDM4EALDH1A1TSHR | |
| SCHEMBL23937732 | 0.63 | CYP11B1 (0.36) | — | |
| SCHEMBL12524710 | 0.63 | CHRNA7 (0.41) | NOS3NOS1NOS2PIK3CB | |
| SCHEMBL23937882 | 0.63 | GRM1 (0.36) | PIK3CB | |
| SCHEMBL26538899 | 0.63 | FGFR1 (0.38) | NOS3NOS1NOS2PIK3CBBACE1 | |
| SCHEMBL13514036 | 0.63 | DDB1 (0.37) | PIK3CBKDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL25879959 | 0.62 | HSP90AA1 (0.34) | HPGDPIK3CBTSHRPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |