Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23937734 | 0.86 | NOS3 (0.33) | PIK3CBPRKCI | |
| SCHEMBL23937732 | 0.76 | CYP11B1 (0.36) | — | |
| SCHEMBL13514036 | 0.73 | DDB1 (0.37) | PIK3CB | |
| SCHEMBL20674183 | 0.73 | PIK3CB (0.34) | PIK3CBPRKCIAPPHSD11B1 | |
| SCHEMBL23937882 | 0.69 | GRM1 (0.36) | PIK3CB | |
| SCHEMBL20631760 | 0.69 | XDH (0.35) | PIK3CBPRKCIKDM1A | |
| SCHEMBL12524710 | 0.69 | CHRNA7 (0.41) | PIK3CBAPP | |
| SCHEMBL13824599 | 0.66 | — | — | |
| SCHEMBL21281472 | 0.66 | PIK3CB (0.46) | PIK3CBPRKCIKDM1AHSD11B1 | |
| SCHEMBL23937773 | 0.66 | BRD9 (0.33) | PIK3CBAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |