Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23937731 | 0.76 | PIK3CB (0.33) | — | |
| SCHEMBL23937881 | 0.75 | PARP1 (0.37) | DRD2SLC6A4HRH3HRH4MAP3K5 | |
| SCHEMBL23937883 | 0.75 | GRM1 (0.40) | DRD2SLC6A4MAP3K5 | |
| SCHEMBL23937774 | 0.72 | ELANE (0.34) | CYP11B1CYP11B2DRD2SLC6A4PIP4K2A | |
| SCHEMBL20674172 | 0.70 | TTK (0.36) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL18379156 | 0.69 | CCR1 (0.40) | — | |
| Hydrochloric Acid SCHEMBL31637376 | 0.69 | DRD2 (0.37) | DRD2SLC6A4 | |
| SCHEMBL16167705 | 0.67 | CNR2 (0.38) | DRD2SLC6A4MAP3K5PIP4K2A | |
| SCHEMBL21959623 | 0.66 | PDE10A (0.32) | CYP11B1CYP11B2DRD2SLC6A4 | |
| SCHEMBL21958555 | 0.66 | DGAT1 (0.38) | MAP3K5PIP4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |