Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674248 | 0.84 | HRH4 (0.35) | HRH4PRKD3CLK2DYRK1APRKD2 | |
| SCHEMBL23937743 | 0.82 | FTO (0.34) | HRH4NOTUM | |
| SCHEMBL20674247 | 0.75 | HRH4 (0.34) | HRH4PRKD3CLK2DYRK1APRKD2 | |
| SCHEMBL20674065 | 0.75 | PI4KA (0.36) | HRH4 | |
| SCHEMBL19341247 | 0.75 | HRH4 (0.51) | HRH4PRKD3CLK2DYRK1APRKD2 | |
| SCHEMBL20674251 | 0.73 | PRKD3 (0.37) | HRH4PRKD3CLK2DYRK1APRKD2 | |
| SCHEMBL18711826 | 0.73 | HRH4 (0.36) | HRH4PRKD3CLK2DYRK1APRKD2 | |
| SCHEMBL31514720 | 0.71 | GAA (0.36) | HRH4NOTUM | |
| SCHEMBL28904493 | 0.71 | GAA (0.36) | HRH4NOTUM | |
| SCHEMBL20674252 | 0.71 | PIK3CB (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |