Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.31 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5172554 | 0.77 | ERCC1 (0.35) | ERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL14788233 | 0.77 | ALDH1A1 (0.32) | ALDH1A1FABP4 | |
| SCHEMBL21958624 | 0.73 | BRD4 (0.38) | ERCC1ERCC5FEN1ERCC4ALDH1A1 | |
| SCHEMBL21958623 | 0.71 | ALDH1A1 (0.46) | ALDH1A1FABP4MAPT | |
| SCHEMBL21958619 | 0.71 | — | — | |
| SCHEMBL21958627 | 0.71 | CA2 (0.34) | PTGDR2 | |
| SCHEMBL21958626 | 0.69 | — | — | |
| SCHEMBL23937769 | 0.69 | — | — | |
| SCHEMBL20631049 | 0.69 | — | — | |
| SCHEMBL20631042 | 0.67 | GAA (0.32) | FEN1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |