Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631027 | 0.75 | FEN1 (0.30) | — | |
| SCHEMBL23937805 | 0.74 | KMT2A (0.35) | KMT2APDE7APDE4B | |
| SCHEMBL20673887 | 0.71 | KMT2A (0.33) | KMT2APDE7A | |
| SCHEMBL20674234 | 0.69 | KMT2A (0.32) | KMT2A | |
| SCHEMBL23937800 | 0.68 | NR4A2 (0.40) | KMT2AMEN1 | |
| SCHEMBL20673904 | 0.67 | MAP2K2 (0.41) | KMT2AMEN1 | |
| SCHEMBL20674231 | 0.65 | LMNA (0.43) | KMT2AMEN1 | |
| SCHEMBL22383810 | 0.61 | SLC6A4 (0.48) | KMT2AMEN1 | |
| SCHEMBL12213145 | 0.59 | — | — | |
| SCHEMBL14985269 | 0.59 | KDM1A (0.34) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |