Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921897 | 0.75 | ALOX15 (0.39) | ALOX15GRM4CHRNA7KDM4EMEN1 | |
| SCHEMBL30322673 | 0.73 | CHRNA7 (0.52) | FGFR1ALOX15GRM4CHRNA7KMT2A | |
| SCHEMBL14234175 | 0.71 | GRM4 (0.36) | ALOX15GRM4CHRNA7POLB | |
| SCHEMBL12248509 | 0.71 | GRM4 (0.36) | ALOX15GRM4CHRNA7KDM4ENPC1 | |
| SCHEMBL14212420 | 0.71 | GRM4 (0.36) | ALOX15GRM4CHRNA7ALDH1A1SMN1; SMN2 | |
| SCHEMBL27629541 | 0.71 | GRM4 (0.36) | ALOX15GRM4CHRNA7 | |
| SCHEMBL29941777 | 0.69 | ALOX15 (0.43) | ALOX15GRM4CHRNA7KDM4EMEN1 | |
| SCHEMBL16864227 | 0.68 | CHRNA7 (0.48) | ALOX15GRM4CHRNA7KDM4EBACE1 | |
| SCHEMBL12647741 | 0.68 | CHRNA7 (0.48) | ALOX15GRM4CHRNA7KDM4EBACE1 | |
| Hydrochloric Acid SCHEMBL5917945 | 0.68 | CHRNA7 (0.48) | ALOX15GRM4CHRNA7KDM4EBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |