Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | CBLB | Q13191 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ADA | P00813 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758975 | 0.86 | CHRNA7 (0.49) | CHRNA7CBLBBACE1GRM4NAMPT | |
| Hydrochloric Acid SCHEMBL5917945 | 0.84 | CHRNA7 (0.48) | CHRNA7CBLBBACE1GRM4NAMPT | |
| SCHEMBL12647741 | 0.84 | CHRNA7 (0.48) | CHRNA7CBLBBACE1GRM4NAMPT | |
| SCHEMBL16864227 | 0.84 | CHRNA7 (0.48) | CHRNA7CBLBBACE1GRM4NAMPT | |
| SCHEMBL12664187 | 0.80 | CHRNA7 (0.45) | CHRNA7CBLBBACE1GRM4NAMPT | |
| SCHEMBL1867606 | 0.80 | CHRNA7 (0.48) | CHRNA7CBLBBACE1LCKLMNA | |
| SCHEMBL23937809 | 0.73 | PLK4 (0.41) | CHRNA7BACE1GRM4ALOX15FGFR1 | |
| SCHEMBL6921897 | 0.73 | ALOX15 (0.39) | CHRNA7CBLBGRM4ALOX15KMT2A | |
| SCHEMBL21580125 | 0.72 | CHRNA7 (0.49) | CHRNA7CBLBLCK | |
| SCHEMBL6417447 | 0.70 | CHRNA7 (1.00) | CHRNA7CBLBBACE1GPR6PRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600312-B1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICALS CO (JP) | 2023-05-17 | — | — | EP | claimed |
| CN-110520127-B | Piperidinyl-substituted and piperazinyl-substituted heteroaromatic carboxamides as modulators of GPR6 | 武田药品工业株式会社 | 2023-05-16 | — | — | CN | claimed |
| CN-118239937-A | Compounds, compositions, and methods | 戴纳立制药公司 | 2024-06-25 | — | — | CN | disclosed |