Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21959650 | 0.82 | ALDH1A1 (0.34) | ALDH1A1 | |
| SCHEMBL21959651 | 0.79 | ALDH1A1 (0.33) | ALDH1A1LMNA | |
| SCHEMBL23937779 | 0.76 | CNOT7 (0.34) | BAZ2BSMN1; SMN2TP53 | |
| SCHEMBL21958625 | 0.72 | ERCC1 (0.36) | BAZ2BSMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL21959652 | 0.69 | KDM4E (0.33) | BAZ2BSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL13485303 | 0.67 | NAMPT (0.53) | NPC1RAB9A | |
| SCHEMBL1231822 | 0.66 | CFTR (0.36) | — | |
| SCHEMBL18337793 | 0.66 | CFTR (0.36) | — | |
| SCHEMBL21955857 | 0.66 | FEN1 (0.37) | BAZ2BSMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL27699410 | 0.65 | KDM4E (0.53) | ALDH1A1NPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |