Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.38 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142239 | 0.78 | PTPN1 (0.41) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL20139203 | 0.77 | PTPN1 (0.43) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL20141604 | 0.77 | AR (0.38) | HPGDGAAKMT2AMAPTMEN1 | |
| SCHEMBL18032960 | 0.76 | DRD4 (0.41) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL20674556 | 0.75 | KDM4E (0.43) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL2743125 | 0.73 | CNR2 (0.55) | PTPN2 | |
| SCHEMBL20927196 | 0.72 | HTR4 (0.44) | KDM4EALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL14627434 | 0.72 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL25539525 | 0.70 | CNR2 (0.50) | KDM4EALDH1A1HPGDGAAKMT2A | |
| SCHEMBL14629325 | 0.69 | KDM4E (0.46) | KDM4EALDH1A1HPGDGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |