Sugi Predict

Sugi Predict / Compounds / SCHEMBL23937965

SCHEMBL23937965

SCHEMBL23937965

CSN1CCN(c2ccc(-c3nc4c(NC5CCN(C(C)C)CC5)c(Cl)cnc4[nH]3)cc2)CC1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ JAK1 P23458 2/20 0.41
▸ JAK2 O60674 1/20 0.41
▸ JAK3 P52333 1/20 0.41
▸ DGAT1 O75907 14/20 0.39
▸ INSR P06213 2/20 0.37
▸ ALK Q9UM73 2/20 0.37
▸ VCP P55072 1/20 0.34
▸ MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23937992 0.91 JAK1 (0.49) JAK1JAK2JAK3DGAT1INSR
SCHEMBL23937990 0.91 JAK2 (0.51) JAK1JAK2JAK3DGAT1INSR
SCHEMBL23937956 0.90 TBK1 (0.41) JAK1JAK2JAK3DGAT1INSR
SCHEMBL30520757 0.90 JAK1 (0.42) JAK1JAK2JAK3DGAT1INSR
SCHEMBL19779001 0.90 JAK1 (0.42) JAK1JAK2JAK3DGAT1INSR
SCHEMBL19778620 0.89 INSR (0.43) JAK1JAK2JAK3DGAT1INSR
SCHEMBL30520578 0.89 INSR (0.43) JAK1JAK2JAK3DGAT1INSR
SCHEMBL30520519 0.88 JAK1 (0.47) JAK1JAK2JAK3DGAT1INSR
SCHEMBL23937978 0.88 JAK1 (0.41) JAK1JAK2JAK3DGAT1INSR
SCHEMBL19778623 0.88 JAK1 (0.47) JAK1JAK2JAK3DGAT1INSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3481824-B1 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY KANCERA AB (SE) 2021-10-20 — — EP disclosed