Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.43 |
| ▸ | INSR | P06213 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19778608 | 0.93 | INSR (0.48) | TBK1INSRALKIKBKEJAK1 | |
| SCHEMBL30521313 | 0.93 | INSR (0.48) | TBK1INSRALKIKBKEJAK1 | |
| SCHEMBL23937981 | 0.91 | TBK1 (0.41) | TBK1INSRALKIKBKEJAK1 | |
| SCHEMBL23937956 | 0.91 | TBK1 (0.41) | TBK1INSRALKIKBKEJAK1 | |
| SCHEMBL23937990 | 0.89 | JAK2 (0.51) | INSRALKJAK1JAK2JAK3 | |
| SCHEMBL19778998 | 0.89 | TBK1 (0.44) | TBK1INSRALKIKBKEJAK1 | |
| SCHEMBL30520984 | 0.89 | TBK1 (0.44) | TBK1INSRALKIKBKEJAK1 | |
| SCHEMBL19778636 | 0.89 | TBK1 (0.48) | TBK1INSRALKIKBKEJAK1 | |
| SCHEMBL30520780 | 0.89 | TBK1 (0.48) | TBK1INSRALKIKBKEJAK1 | |
| SCHEMBL19778635 | 0.88 | TBK1 (0.55) | TBK1INSRALKIKBKEJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481824-B1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2021-10-20 | — | — | EP | disclosed |