Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19778630 | 0.97 | TBK1 (0.44) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL30520727 | 0.97 | TBK1 (0.44) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL30521313 | 0.93 | INSR (0.48) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL19778608 | 0.93 | INSR (0.48) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL19778629 | 0.92 | TBK1 (0.42) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL30520772 | 0.92 | TBK1 (0.42) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL30521383 | 0.91 | TBK1 (0.52) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL19778637 | 0.91 | TBK1 (0.52) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL23937956 | 0.91 | TBK1 (0.41) | INSRALKTBK1IKBKEJAK1 | |
| SCHEMBL19778921 | 0.90 | AURKA (0.42) | INSRALKTBK1IKBKEJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481824-B1 | 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2021-10-20 | — | — | EP | disclosed |