Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23938457 | 0.88 | TACR1 (0.42) | TACR1MEN1KMT2AKCNH2CCR2 | |
| SCHEMBL18244949 | 0.85 | TACR1 (0.45) | TACR1MEN1KMT2AMAPK1HTT | |
| SCHEMBL18252890 | 0.83 | KCNH2 (0.46) | TACR1MEN1KMT2AMAPK1HTT | |
| SCHEMBL13887070 | 0.74 | KCNH2 (0.47) | TACR1MEN1KMT2AMAPK1HTT | |
| SCHEMBL18244998 | 0.74 | TACR1 (0.46) | TACR1MEN1KMT2AKCNH2CCR2 | |
| SCHEMBL23938458 | 0.74 | CCR2 (0.57) | TACR1KCNH2CCR2 | |
| SCHEMBL24433859 | 0.73 | TACR1 (0.43) | TACR1MEN1KMT2AKCNH2CCR2 | |
| SCHEMBL19443100 | 0.73 | TACR1 (0.43) | TACR1MEN1KMT2AKCNH2CCR2 | |
| SCHEMBL21900422 | 0.73 | TACR1 (0.43) | TACR1MEN1KMT2AKCNH2CCR2 | |
| SCHEMBL23938481 | 0.72 | KCNH2 (0.50) | TACR1KCNH2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297438-B1 | CCR2 MODULATORS | CHEMOCENTRYX INC (US) | 2021-10-20 | — | — | EP | disclosed |