Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 3/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18301358 | 0.86 | NPBWR1 (0.44) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL29161724 | 0.84 | TSHR (0.50) | PKMPKLRP2RX7ALDH1A1MAPT | |
| SCHEMBL759935 | 0.81 | NPBWR1 (0.44) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL530059 | 0.79 | IDO1 (0.47) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL2961568 | 0.78 | PDE1B (0.52) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL29433484 | 0.76 | BRD4 (0.53) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL27242636 | 0.76 | NPBWR1 (0.47) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL20176889 | 0.76 | NPBWR1 (0.47) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL5091051 | 0.76 | BRD4 (0.53) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL24785427 | 0.76 | NPBWR1 (0.43) | NPBWR1MCHR1P2RX7MAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307733-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2021-10-20 | — | — | EP | disclosed |