Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30469042 | 0.85 | NPBWR1 (0.54) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL27242636 | 0.84 | NPBWR1 (0.47) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL21579413 | 0.81 | NPBWR1 (0.44) | NPBWR1MCHR1PKMPKLRALDH1A1 | |
| SCHEMBL25753127 | 0.80 | NPBWR1 (0.49) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL30051137 | 0.80 | NPBWR1 (0.46) | NPBWR1MCHR1KDM4E | |
| SCHEMBL22139429 | 0.80 | NPBWR1 (0.48) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL30050755 | 0.79 | PDE8B (0.46) | NPBWR1MCHR1ALOX15CYP11B1CYP11B2 | |
| SCHEMBL30408409 | 0.79 | NPBWR1 (0.46) | NPBWR1MCHR1BRD4ALDH1A1KDM4E | |
| SCHEMBL23938744 | 0.76 | NPBWR1 (0.46) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL30498344 | 0.76 | NPBWR1 (0.48) | NPBWR1MCHR1PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092047-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2018-05-24 | — | — | WO | disclosed |