Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.35 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19504239 | 0.85 | CRBN (0.45) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL19504240 | 0.76 | CRBN (0.53) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL14275306 | 0.75 | CRBN (0.55) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL25036572 | 0.74 | CRBN (0.43) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL19630886 | 0.74 | CRBN (0.41) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL17724241 | 0.73 | CRBN (0.58) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL17724243 | 0.73 | CRBN (0.58) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL17724217 | 0.73 | CRBN (0.58) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL19503553 | 0.73 | CRBN (0.47) | CRBNIKZF1DDB1IKZF3BRD4 | |
| SCHEMBL17724040 | 0.71 | CRBN (0.66) | CRBNIKZF1CSNK1A1DDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643709-B1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2021-10-20 | — | — | EP | disclosed |