Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 10/20 | 0.47 |
| ▸ | TNF | P01375 | 6/20 | 0.44 |
| ▸ | IL1B | P01584 | 4/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503563 | 0.88 | CRBN (0.45) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19504239 | 0.81 | CRBN (0.45) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL24042667 | 0.80 | CRBN (0.53) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL3542188 | 0.80 | CRBN (0.70) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL21303951 | 0.80 | CRBN (0.70) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL20645750 | 0.80 | CRBN (0.70) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19504240 | 0.79 | CRBN (0.53) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19612061 | 0.76 | CRBN (0.61) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL18270944 | 0.76 | CRBN (0.61) | CRBNIKZF3TNFIL1BDDB1 | |
| SCHEMBL19503552 | 0.74 | WIZ (0.45) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184995-A1 | COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF | BIOVENTURES, LLC (US) | 2017-10-26 | — | — | WO | disclosed |