Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 2/20 | 0.44 |
| ▸ | IL1B | P01584 | 2/20 | 0.44 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19504240 | 0.88 | CRBN (0.53) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL23939137 | 0.85 | CRBN (0.42) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL25036572 | 0.83 | CRBN (0.43) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL19503553 | 0.81 | CRBN (0.47) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL15711555 | 0.80 | CRBN (0.70) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL21304411 | 0.80 | CRBN (0.70) | CRBNDDB1IKZF3IKZF1BRD4 | |
| Hydrochloric Acid SCHEMBL1424536 | 0.79 | CRBN (0.69) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL25679573 | 0.79 | CRBN (0.61) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL19503563 | 0.79 | CRBN (0.45) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL19503817 | 0.78 | CRBN (0.54) | CRBNDDB1IKZF3IKZF1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184995-A1 | COMPOUNDS THAT INDUCE DEGRADATION OF ANTI-APOPTOTIC BCL-2 FAMILY PROTEINS AND THE USES THEREOF | BIOVENTURES, LLC (US) | 2017-10-26 | — | — | WO | disclosed |